About Us: 
The Pilot Bioproduction Facility (PBF) plays a crucial role in developing vaccines and biologics for military-relevant infectious disease threats. Our mission is to support biologics manufacturing for WRAIR, the U.S. Army, the DoD, and external academic and industry partners.  As the DoD's primary in-house Phase I biologics manufacturer, we are a trusted resource for GMP-compliant pharmaceutical production, bridging the gap between R&D and early Phase clinical trials for vaccines and biologics. 

Full Spectrum Support:
Tech transfer, manufacturing process development, cell and viral banking, drug substance and drug product manufacturing, analytical testing, and stability services.

Our GMP Services include: 
Recombinant Protein Production: In mammalian cells, bacteria, and yeast 
Microbial Fermentations: BSL-2 up to 400L scale 
Mammalian Cell Culture Capabilities : Including monoclonal antibody productions (up to 40L scale)
Scalable Purification Expertise: Depth Filtration, Chromatography, Tangential Flow Filtration, and more  
Viral Vaccine Production: BSL-2 attenuated and inactivated vaccine production
Challenge Strains: Viral, bacterial, and parasitic  
mRNA Vaccine Production: in vitro transcription up to 300 mL scale  
Formulation & fill/finish: Liquid fill or lyophilization up to 2,000 vials per lot
Full Quality Management System: Ensuring GMP compliance for Phase I trials 
 
Join Us in Advancing Health Innovations
PBF is committed to supporting the rapid demonstration of proof-of-concept for vaccines and biologics. Explore our partnership opportunities today! 

Contact Us
Walter Reed Army Institute of Research 
Pilot Bioproduction Facility 
503 Robert Grant Avenue 
Building 501 
Silver Spring, MD 20910-7500

Email: usarmy.detrick.medcom-wrair.mbx.pilot-bio-production-facility@health.mil

Main Number: (301) 319-9152